Table 1 Details of the number of genetic instruments and F-statistic for each cytokine and growth factor

Beta nerve growth factor

β-NGF

4

25.72(20.83–35.43)

0.029

Cutaneous T-cell attracting (CCL27)

CTACK

10

39.41(20.84–139.89)

0.097

Eotaxin (CCL11)

Eotaxin

18

47.81(20.85–203.72)

0.095

Basic fibroblast growth factor

FGF-basic

8

24.77(20.79–25.40)

0.024

Granulocyte colony-stimulating factor

G-CSF

5

25.37(21.85–25.80)

0.016

Growth regulated oncogene-α (CXCL1)

GRO-a

7

100.62(21.17–248.86)

0.166

Hepatocyte growth factor

HGF

7

30.53(21.23–55.42)

0.025

Interferon-gamma

IFN-γ

8

23.69(21.47–24.99)

0.024

Interleukin-1 receptor antagonist

IL-1rα

6

22.84(20.89–24.25)

0.036

Interleukin-1-beta

IL-1β

4

22.81(21.78–23.04)

0.027

Interleukin-2

IL-2

7

23.86(20.94–27.62)

0.045

Interleukin-2 receptor, alpha subunit

IL-2rα

6

49.28(21.12–170.04)

0.074

Interleukin-4

IL-4

11

26.80(21.22–28.03)

0.035

Interleukin-5

IL-5

7

25.23(21.19–38.39)

0.049

Interleukin-6

IL-6

8

23.87(21.23–30.71)

0.023

Interleukin-7

IL-7

4

60.73(20.84–169.54)

0.066

Interleukin-8 (CXCL8)

IL-8

5

22.77(21.10–23.85)

0.031

Interleukin-9

IL-9

4

23.50(21.54–26.37)

0.025

Interleukin-10

IL-10

14

46.17(21.26–300.09)

0.077

Interleukin-12p70

IL-12p70

13

76.58(20.89–559.19)

0.100

Interleukin-13

IL-13

9

56.52(20.88–292.36)

0.124

Interleukin-16

IL-16

8

44.72(21.99–133.68)

0.092

Interleukin-17

IL-17

6

25.45(20.95–35.94)

0.019

Interleukin-18

IL-18

11

48.72(21.83–100.11)

0.128

Interferon gamma-induced protein 10 (CXCL10)

IP-10

7

24.20(21.24–26.86)

0.044

Monocyte chemotactic protein-1 (CCL2)

MCP-1

18

50.77(21.45–201.44)

0.099

Monocyte-specific chemokine 3 (CCL7)

MCP-3

6

25.08(20.77–26.39)

0.121

Macrophage colony-stimulating factor

M-CSF

5

24.30(20.96–30.98)

0.046

Macrophage migration inhibitory factor (glycosylation-inhibiting factor)

MIF

8

26.56(21.25–38.68)

0.057

Monokine induced by interferon-gamma (CXCL9)

MIG

7

27.44 (21.62–41.56)

0.049

Macrophage inflammatory protein-1α (CCL3)

MIP-1α

2

22.24(21.83–22.40)

0.012

Macrophage inflammatory protein-1β (CCL4)

MIP-1b

28

120.68(21.55–603.64)

0.290

Platelet-derived growth factor-BB

PDGF-bb

12

52.83(21.17–240.19)

0.071

Regulated on activation, normal T Cell expressed and secreted (CCL5)

RANTES

9

26.21(20.84–34.93)

0.064

Stem cell factor

SCF

9

28.01(22.13–48.08)

0.029

Stem cell growth factor beta

SCGF-β

15

95.48(20.90–96.22)

0.147

Stromal cell-derived factor-1 alpha (CXCL12)

SDF-1α

5

22.42(20.91–23.36)

0.014

Tumor necrosis factor-alpha

TNF-α

2

22.88(22.40–23.07)

0.013

Tumor necrosis factor-beta

TNF-β

3

23.35(21.8–24.60)

0.043

TNF-related apoptosis-inducing ligand

TRAIL

13

42.63(21.28–138.48)

0.063

Vascular endothelial growth factor

VEGF

15

90.67(20.88–781.85)

0.160

Myeloproliferative neoplasms

MPN

5

64.80(45.07–117.72)

0.001