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Table 1 Distribution of patient characteristics at diagnosis by disease stage and associated adjusted odds ratios for late versus early-stage CRC presentation

From: Demographic and clinical characteristics associated with advanced stage colorectal cancer: a registry-based cohort study in Saudi Arabia

Characteristics

Early-stage

N (%)

Late-stage

N (%)

OR (95%CI)

12,402 (70.7)

5,139 (29.3)

Age in yrs, mean (SD)

 

57.93 (14.8)

57.81 (14.9)

 

Age group in yrs

0–39

1383 (11.2)

598 (11.6)

1.10 (0.99, 1.22)

 

40–49

2103 (17.0)

936 (18.2)

1.13 (1.03, 1.23)

 

50–59

3113 (25.1)

1222 (23.8)

1.00 P = 0.01

 

60–69

2941 (23.7)

1170 (22.8)

1.03 (0.93, 1.12)

 

70–79

2013 (16.2)

859 (16.7)

1.11 (1.00, 1.21)

 

80+

843 ( 6.8)

353 ( 6.9)

1.09 (0.95, 1.23)

Sex

Male

6930 (55.9)

2713 (52.8)

1.00 P < 0.001

 

Female

5472 (44.1)

2426 (47.2)

1.12 (1.06, 1.19)

Marital status

Married

10,020 (89.9)

4169 (88.0)

1.00 P < 0.01

 

Unmarried

1126 (10.1)

568 (12.0)

1.09 (0.98, 1.19)

Region

Riyadh

3787 (30.8)

1583 (31.1)

1.00 P < 0.0001

 

Eastern

2031 (16.5)

961 (18.9)

1.13 (1.03, 1.23)

 

Makkah

3150 (25.6)

1200 (23.6)

0.91 (0.83, 1.00)

 

Madina

705 ( 5.7)

235 ( 4.6)

0.81 (0.65, 0.96)

 

Asir

911 ( 7.4)

346 ( 6.8)

0.91 (0.77, 1.05)

 

Jazan

239 ( 1.9)

77 ( 1.5)

0.77 (0.51, 1.04)

 

Najran

115 ( 0.9)

53 ( 1.0)

1.09 (0.76, 1.42)

 

Hail

224 ( 1.8)

108 ( 2.1)

1.15 (0.91, 1.39)

 

Qassim

564 ( 4.6)

250 ( 4.9)

1.06 (0.90, 1.22)

 

Baha

198 ( 1.6)

57 ( 1.1)

0.68 (0.38, 0.98)

 

Jouf

86 ( 0.7)

59 ( 1.2)

1.63 (1.30, 1.97)

 

Northern

67 ( 0.5)

45 ( 0.9)

1.59 (1.21, 1.98)

 

Tabuk

237 ( 1.9)

118 ( 2.3)

1.18 (0.95, 1.41)

Diagnosis date

1997–2001

1112 ( 9.0)

348 ( 6.8)

1.00 P < 0.0001

 

2002–2006

2054 (16.6)

823 (16.0)

1.28 (1.14, 1.43)

 

2007–2011

3336 (26.9)

1492 (29.0)

1.43 (1.30, 1.57)

 

2012–2017

5900 (47.6)

2476 (48.2)

1.34 (1.21, 1.47)

Anatomical site

Colon

7513 (60.6)

3027 (58.9)

1.00 P < 0.01

 

Rectosigmoid

1847 (14.9)

873 (17.0)

1.17 (1.08, 1.27)

 

Rectal

3042 (24.5)

1239 (24.1)

1.01 (0.93, 1.09)

  1. Note: CI: Confidence interval; N: Number; OR: Odds ratios adjusted for all factors in the table using complete stage data and multiple imputation of covariates; SD: Standard deviation. The p-values are derived from the overall likelihood ratio tests for association. Number and percentage of missing values relative to the dataset with known cancer stage: Age at diagnosis (n = 7, 0.04%); Marital status (n = 1658, 9.5%); Geographical region (n = 135, 0.8%). Percentages are presented by column to characterise patients’ profiles for patients with late-stage and early-stage CRC
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BMC Cancer

ISSN: 1471-2407

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