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Fig. 5 | BMC Cancer

Fig. 5

From: Desmoglein 2 and desmocollin 2 depletions promote malignancy through distinct mechanisms in triple-negative and luminal breast cancer

Fig. 5

Dsg2 and Dsc2 depletions both enhanced migration and invasion of BC cells. (A) Wound-healing assays and quantitative analysis showed a significant promotion of migration at 48 h for shDsg2 and shDsc2 MDA-MB-231 cells and at 72 h for shDsg2 and shDsc2 MCF-7 cells compared with their controls. (B) Transwell migration and invasion assays. The images of migrated cells were photographed after 24 h for seeding derived cells from MDA-MB-231 cells and 48 h for seeding derived cells from MCF-7 cells. The images of invaded cells were photographed at 48 h for MDA-MB-231 cells and 72 h for MCF-7 cells. The scale bar represents 100 μm. Data are presented as mean ± SD from three separate experiments. *indicates P < 0.05

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BMC Cancer

ISSN: 1471-2407

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